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AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery - Trial NCT03965494

Access comprehensive clinical trial information for NCT03965494 through Pure Global AI's free database. This Early Phase 1 trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and is currently Recruiting. The study focuses on Brain and Central Nervous System Tumors. Target enrollment is 20 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.

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NCT03965494
Early Phase 1
Recruiting
drug
Trial Details
ClinicalTrials.gov โ€ข NCT03965494
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AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery
Pilot Surgical PK Study of BGB324 in Recurrent Glioblastoma Patients

Study Focus

BGB 324 (before surgery)

Interventional

drug

Sponsor & Location

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Birmingham,Baltimore,Detroit,New York,Winston-Salem,Philadelphia, United States of America

Timeline & Enrollment

Early Phase 1

Jan 02, 2020

Dec 01, 2023

20 participants

Primary Outcome

Proportion of patients who achieve a drug concentration at = 1.0 uM level in contrast enhancing tumor tissue

Summary

This phase I trial studies how well AXL inhibitor BGB324 works in treating participants with
 glioblastoma that has come back who are undergoing surgery. AXL inhibitor BGB324 may stop the
 growth of tumor cells by blocking some of the enzymes needed for cell growth.

ICD-10 Classifications

Malignant neoplasm: Overlapping lesion of brain and other parts of central nervous system
Malignant neoplasm: Central nervous system, unspecified
Benign neoplasm of brain and other parts of central nervous system
Malignant neoplasm of brain
Secondary malignant neoplasm of other and unspecified parts of nervous system

Data Source

ClinicalTrials.gov

NCT03965494

Non-Device Trial