VEGFR/PDGFR Dual Kinase Inhibitor X-82 and Docetaxel in Treating Patients With Solid Tumors - Trial NCT02146222
Access comprehensive clinical trial information for NCT02146222 through Pure Global AI's free database. This Phase 1 trial is sponsored by University of Wisconsin, Madison and is currently Completed. The study focuses on Unspecified Adult Solid Tumor, Protocol Specific. Target enrollment is 14 participants.
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Study Focus
VEGFR/PDGFR dual kinase inhibitor X-82
Interventional
drug
Sponsor & Location
University of Wisconsin, Madison
Timeline & Enrollment
Phase 1
Sep 01, 2014
Dec 01, 2016
Primary Outcome
Incidence of toxicity graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.0 (Pharmacodynamic study),Changes in the FLT PET/CT vascular parameters for VEGF/PDGF dual kinase inhibitor X-82,Changes in the FLT PET/CT vascular parameters for the combination of VEGFR/PDGFR dual kinase inhibitor X-82 and docetaxel
Summary
This partially randomized phase I trial studies the side effects and how well sequential
 dosing of vascular endothelial growth factor receptor (VEGFR)/platelet derived growth factor
 receptor (PDGFR) dual kinase inhibitor X-82 and docetaxel works in treating patients with
 solid tumors. VEGFR/PDGFR dual kinase inhibitor X-82 may stop the growth of tumor cells by
 blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as
 docetaxel, work in different ways to stop the growth of tumor cells, either by killing the
 cells, by stopping them from dividing, or by stopping them from spreading. Giving VEGFR/PDGFR
 dual kinase inhibitor X-82 and docetaxel one at a time instead of concurrently may work in
 treating patients with solid tumors.
ICD-10 Classifications
Data Source
ClinicalTrials.gov
NCT02146222
Non-Device Trial