Efficacy and Safety of Low-dose Cannabidiol for anxiety - Trial ANZCTR12623000803695

Timeline & Enrollment

Primary Outcome

Efficacy of low-dose CBD for anxiety as measured using Generalised Anxiety Disorder (GAD-7) assessment

Summary

This study aims to determine the efficacy and safety of low-dose cannabidiol for anxiety. Cannabidiol or CBD is a major component originally derived from the Cannabis plant and works on cannabinoid receptors. There are two types of cannabinoid receptors, CB1 mainly in the brain and CB2 mainly in the immune system. These two receptors help regulate things like sleep, mood, pain and more. This study will be investigating if low-dose CBD will improve anxiety when compared to a placebo or inactive drug. CBD has been used for a number of conditions but there are limited clinical studies for individual products and conditions. There is evidence that low-dose CBD is safe to use and the Therapeutic Goods Administration (TGA) has scheduled low-dose CBD (maximum of 150mg per day) as Schedule 3 or pharmacist only due to the acceptable safety and tolerability profile. There is evidence to suggest CBD is effective for anxiety but more clinical studies are needed, including for this particular formulation. This is a clinical trial into whether CBD is effective for anxiety compared to a placebo or inactive drug. If more studies like this one provide supports the safe and effective use of CBD for anxiety then patients, doctors and other health professionals will feel more confident recommending CBD for this condition.

ICD-10 Classifications